Yes: Redmond, Oregon (RDM) is about 25 minutes away, and Portland, Oregon (PDX) is about 3 ½ hours away. Both of these airports have scheduled airlines flying in and out of them.
General aviation out of Redmond (KRDM) and Sisters (6K5) is also available.
Complimentary transportation to and from the Redmond Airport is provided, and can also be arranged for transportation from Sisters. If your stay will require this service, please make arrangements at the time of booking.